1st baby born from deceased organ donor's womb

Doctors hold a baby girl born to a mother who received a uterus from a deceased donor in Brazil. A novel transplantation procedure may help more infertile women become pregnant

A woman who received a uterus transplant from a deceased donor has given birth to a healthy baby girl, according to a paper in the Lancet.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams, the case study said. In the first, the uterus had to be removed from the recipient after an infection occurred; Flyckt said she couldn't say where things stood with the second case other than that the recipient was doing well.

The mother was a 32-year-old woman with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome - a condition that causes female sexual reproductive organs, such as the uterus and vagina, to be underdeveloped or absent at birth.

The woman became pregnant through in vitro fertilisation seven months after the transplant.

While babies born from live donor uterus transplants have been done almost a dozen times before, including once in 2017 at Baylor Scott & White Hospital in Dallas, this birth marks the first time doctors have been able to remove the uterus from a recently deceased donor and have it result in a live birth.

The first successful childbirth following uterine transplant from a living donor took place in 2014 in Sweden, and there have been 10 others since then.

"The use of deceased donors could greatly broaden access to this treatment, and our results provide proof-of-concept for a new option for women with uterine infertility", Dr. Dani Ejzenberg, a gynecologist in Sao Paulo who led the research, said in a news release. Until now, the only successful uterus transplants have involved living donors who are typically family members of the recipients.

According to reports, the success of this procedure means that there will be a larger option of donors available for those who have trouble conceiving because of uterine factor infertility. Almost a year later, mother and baby are both healthy.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised. "Now she comes in to show us the baby and she is so happy", he said.

After surgery, the anonymous recipient remained in intensive care for two days before spending another six days on a specialised transplant ward.

The donated uterus was removed during the C-section and the woman's wound healed well, the researchers say. A baby has been born to a mother who had a uterus transplant from a deceased owner for the first time.

Surgeons spent 10.5 hours plumbing in the organ by connecting veins, arteries, ligaments and vaginal canals. The mother is the first in the world to give birth after such a transplant, a feat doctors were not sure would ever be possible.

"I don't know that they're highlighted enough when we're celebrating these kind of breakthroughs", she said. Fifteen were fertilised, with 8 resulting in embryos that were subsequently preserved for later implantation.

"They should also encourage forthcoming procedures to be done and reported in a transparent way by endorsing prospective registration of the procedures and by developing accurate registries".

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