Study links oral antibiotic use to possible painful side effect

Antibiotics May Raise the Risk for Kidney Stones

It showed patients who took oral antibiotics were more likely to develop kidney stones up to fie years later. This is the first time that these drugs are associated with this disease.

Oral antibiotics could be responsible for the dramatic increase of kidney stones, according to a new study that covered 13 million people.

Dr. Tasian's findings will appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

While diet trends, such as more soda and caffeine, and less water are likely factors, the doctor's team chose to look at common medications, like antibiotics, which are prescribed to children much more than adults. The team analyzed prior antibiotic exposure for almost 26,000 patients with kidney stones, compared to almost 260,000 control subjects. They tracked antibiotic exposure three to 12 months before the diagnosis. Just because children are prescribed more of them as compared to adults, researchers suggest that the clinicians need to be more honest and mindful while prescribing medication especially when they are dealing with young patients. The risk of nephrolithiasis decreased over time, but it remained elevated at 3-5 years after the antibiotic prescription.

About 30 percent of prescribed antibiotics are inappropriate, Tasian noted, and because children receive more of them than any other age group, the researchers' findings reinforce the need for clinicians to be more mindful of prescriptions, especially if the recipients are children. The condition is, however, associated with bacterial changes in the intestines and urinary tract, leading investigators to study the relationship between antibiotics and kidney stones.

One co-author of the current paper, Jeffrey Gerber, MD, PhD, is an infectious diseases specialist at CHOP who leads programs in antibiotic stewardship-;an approach that guides healthcare providers in prescribing the most appropriate antibiotic for each patient's specific infection, with the aims of improving individual outcomes and reducing the overall risk of antibiotic resistance.

Tasian along with his fellow mates is planning to go for full proof investigation of microbiomes in the children and adolescent's body in the near future. Their goal is to expand this research into broader, population-based studies to better understand how variations in microbiome composition may influence the development of kidney stones.



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