FDA Warns That Kratom May Be Similar To Opioids

FDA Warns That Kratom May Be Similar To Opioids

"It's an opioid", Gottlieb continued.

Based on the new FDA new research, along with information from previous studies and reports of harmful effects tied to kratom, "we feel confident in calling compounds found in kratom, opioids", Gottlieb said in a statement. Other people who died after taking kratom tended to have mixed it with other drugs of various kinds.

Gottlieb said the FDA has been especially concerned about kratom's use to treat opioid withdrawal symptoms, and warned against it.

"Kratom has been proven to be a safe botanical used by consumers for centuries, and it is the very lack of using competent personnel and equipment in investigations on the cause of alleged overdose deaths that has led to numerous inaccurate and erroneous conclusions by law enforcement agencies, including the DEA", Dave Herman, chairman of the American Kratom Association told the Advance.

"The new data provides even stronger evidence of kratom compounds' opioid properties", Gottlieb said on Tuesday. Using this model, FDA scientists analyzed the chemical structures of the 25 most prevalent compounds in kratom and found that they all share the most structural similarities with controlled opioid analgesics, such as morphine derivatives.

While this concern is legitimate, there is no way to know precisely how kratom does - or doesn't - work without rigorous scientific testing, which has not yet been done.

Additionally, the researchers found that 22 of the 25 compounds in kratom bind to mu-opioid receptors, and that some of the compounds may bind to receptors in the brain that may contribute to stress responses that impact neurologic and cardiovascular function.

According to the Centers for Disease Control and Prevention, an opioid is a natural or synthetic chemical that interacts with opioid receptors. FDA has thus created the Public Health Assessment via Structural Evaluate (PHASE) methodology, which helps simulate, using 3-D computer technology, how the chemical constituents of a substance are structured at the molecular level, how they behave inside the body, and how they can potentially affect the brain. That's because "the activity of kratom at opioid receptors indicates there may be similar risks of combining kratom with certain drugs, just as there are with FDA-approved opioids", Gottlieb said.

There's still a lot we don't know about kratom. Across the United States, several reports of deaths and addiction led the Drug Enforcement Administration to place kratom on its list of "drugs and chemicals of concern".

The FDA does not now approve kratom for any therapeutic uses.

It wasn't the first time. On the bright side, most of the calls reported minimal to moderate side effects, though there was one death recorded.

"Whether it's on the bottle or not, there can be ingredients in there that can do harm".



Other news